• Marilia Alves Dos Reis, Ary Gadelha, André C Felício, Marcelo Queiroz Hoexter, Ilza Rosa Batista, Pedro Braga-Neto, Mariana Calzavara, Daniel Alves Cavagnolli, Cinthia Higuchi, Melissa Furlaneto Lellis Leite, Solange Amorim Nogueira, Jairo Wagner, Mario Luiz Vieira Castiglioni, Ming Chi Shih, and Rodrigo Affonseca Bressan.
• Laboratory of Integrative Neuroscience, Universidade Federal de São Paulo (LiNC- EPM/UNIFESP), São Paulo, Brazil.
• Medicine (Baltimore). 2021 Oct 1; 100 (39): e27192e27192.

AbstractThe presynaptic dopamine transporter (DAT) modulates the uptake of dopamine by regulating its concentration in the central nervous system. We aimed to evaluate the DAT binding potential (DAT-BP) in a sample of healthy Brazilians through technetium-99 metastable TRODAT-1 single-photon emission computed tomography imaging.We selected 126 healthy individuals comprising 72 men and 54 women, aged 18 to 80 years. We conducted semi-quantitative evaluation in transaxial slices, following which we identified the regions of interest in the striatal region using the occipital lobe as a region of non-specific DAT-BP.We found a decrease in DAT-BP in healthy individuals aged over 30 years, culminating in a 42% mean reduction after 80 years. There was no difference in the decrease by age group between the right (linear regression test [R2] linear = 0.466) and left striatum (R2 linear = 0.510). Women presented a higher DAT-BP than men (women: R2 linear = 0.431; men: R2 linear = 0.457); nonetheless, their decrease by age group was equal to that in men.Our study sheds light on important DAT-BP findings in healthy Brazilian subjects. Our results will facilitate understanding of brain illnesses that involve the dopamine system, such as neuropsychiatric disorders.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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