• Katriina M Lanning, Tiina M Erkinaro, Pasi P Ohtonen, Merja A Vakkala, Janne H Liisanantti, Laura A Ylikauma, and Timo I Kaakinen.
• Research Group of Surgery, Anesthesiology and Intensive Care Medicine, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland. Electronic address: katriina.lanning@gmail.com.
• J. Cardiothorac. Vasc. Anesth. 2022 Jul 1; 36 (7): 1995-2001.

ObjectiveTo determine whether central venous oxygen saturation (ScvO2) measurements could be used interchangeably with mixed venous oxygen saturation (SvO2) measurements in adult cardiac surgery patients.DesignA single-center prospective observational study.SettingA university hospital.ParticipantsEighty-five adult patients undergoing cardiac surgery.InterventionsThe study authors compared the oxygen saturations in 590 pairs of venous blood samples drawn from the pulmonary artery catheter (PAC) at three different time points during surgery and four different time points in the intensive care unit. They compared samples obtained from the distal pulmonary artery line (SvO2) to those drawn from the proximal central venous line of the PAC (ScvO2) with the Bland-Altman test and the four-quadrant method.Measurements And Main ResultsThe mean bias between SvO2 and ScvO2 was -1.9 (95% confidence interval [CI], -2.3 to -1.5) and the limits of agreement (LOA) were -11.5 to 7.6 (95% CI, -12.5 to -10.7 and 6.8-8.5, respectively). The percentage error (PE) was 13.2%. Based on the four-quadrant plot, only 50% of the measurement pairs were in agreement, indicating deficient trending ability.ConclusionScvO2 values showed acceptable accuracy as the mean bias was low. The precision was inadequate; although the PE was acceptable, the LOA were wide. Trending ability was inadequate. The authors cannot recommend the use of ScvO2 values interchangeably with SvO2 measurements in the management of adult cardiac surgery patients.Copyright © 2021 The Author(s). Published by Elsevier Inc. All rights reserved.

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