• Takashi Saito, Manabu Kakinohana, Osamu Kakinohana, and Kazuhiro Sugahara.
• Department of Anesthesiology, Faculty of Medicine, University of the Ryukyus, Okinawa 903-0125.
• Masui. 2002 Jun 1; 51 (6): 620-3.

AbstractWe examined the blood propofol concentrations when patients responded to vocal command in patients with panperitonitis (Group P:N = 11) and patients for elective laparotomy (Group E:N = 19). In both groups, general anesthesia was induced and maintained by intravenous administration of propofol, fentanyl and ketamine following insertion of an epidural catheter. Blood samples were taken from the left femoral artery at emergence from anesthesia, and blood propofol concentrations were measured by the HPLC. Although the demographic factors and the anesthetic conditions were similar in both groups, the blood propofol concentration at emergence from anesthesia in Group P was significantly higher than that in Group E (1.04 + 0.11 vs 0.84 + 0.14 microgram.ml-1, P = 0.03). Our data suggest that blood propofol levels should be kept higher during propofol anesthesia in patients with panperitonitis.

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