• J J Rongen, M M Rovers, T G van Tienen, P Buma, and G Hannink.
• Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Orthopaedic Research Lab, PO Box 9101, 6500 HB Nijmegen, The Netherlands. Electronic address: Jan.Rongen@radboudumc.nl.
• Osteoarthr. Cartil. 2017 Jan 1; 25 (1): 23-29.

ObjectiveThe primary objective was to assess whether patients with knee osteoarthritis and whom undergo arthroscopic meniscectomy have an increased risk for future knee replacement surgery.DesignData used were obtained from the Osteoarthritis Initiative (OAI) study.SettingParticipants were enrolled, in four clinical centers, between February 2004 and May 2006 and were followed up on an annual basis up to and including 108-months from enrollment.Participants4674 participants (58.4% female), aged 45-79, of all ethnic groups, who had, and those who were at high risk for developing, symptomatic knee osteoarthritis were included, of which 3337 (71.4%) were included in the final follow up visit.Main Outcome MeasuresHazard ratio of knee replacement surgery for participants who underwent arthroscopic meniscectomy during follow up compared to propensity score matched participants who did not undergo arthroscopic meniscectomy during follow up.Results335 participants underwent arthroscopic meniscectomy during follow up, of which 63 (18.8%) underwent knee replacement surgery in the same knee. Of the 335 propensity score matched participants 38 (11.1%) underwent knee replacement surgery during follow up. Results from the Cox-proportional hazards model demonstrated that the hazard ratio of knee replacement surgery was 3.03 (95% CI (1.67-5.26)) for participants who underwent arthroscopic meniscectomy relative to the propensity score matched participants who did not undergo arthroscopic meniscectomy.ConclusionsIn patients with knee osteoarthritis arthroscopic knee surgery with meniscectomy is associated with a three fold increase in the risk for future knee replacement surgery.Copyright © 2016 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

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