• Fabiola Arena, Felice Larocca, and Emanuela Gualdi-Russo.
• Department of Neuroscience and Rehabilitation, University of Ferrara, Ferrara, Italy; Centro Regionale di Speleologia "Enzo dei Medici", Roseto Capo Spulico, Cosenza, Italy.
• World Neurosurg. 2022 Jan 1; 157: 36-44.

AbstractSkull vault trepanation is a surgical practice that has been found in prehistoric human remains. We carried out a review of the literature on cranial trepanations performed during the Bronze Age in Italy. In total, 19 individuals, most of whom were adult males, with 33 trepanations have been reported, including a new specimen from the Italian Middle Bronze Age (1700-1400 BCE), found at Grotta della Monaca (Calabria). The evidence of cranial trepanations is geographically uneven across Italy, with the highest occurrence in Sardinia. Several trepanation techniques were applied in Italy during this period, where the drilling method was the most common solitary technique utilized. The survival rate of 79.3% in Bronze Age Italy suggests that trepanation was carried out with remarkable success. This analysis gives further insight into ancient human behavior and enhances our knowledge of surgical practices in antiquity, shedding light on the origins of neurosurgery.Copyright © 2021 Elsevier Inc. All rights reserved.

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