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- T Taniguchi, K Yamamoto, and T Kobayashi.
- Department of Anesthesiology and Intensive Care Medicine, School of Medicine, Kanazawa University, Japan.
- Can J Anaesth. 1996 May 1; 43 (5 Pt 1): 511-3.
PurposeTo determine the composition and solubility of the precipitate formed by thiopentone and vecuronium in vitro.MethodsThe precipitate formed by mixing thiopentone 2.5% and vecuronium 0.1% at room temperature was analyzed by ultraviolet spectrophotometry and high performance liquid chromatography (HPLC). The solubility of the precipitate in human plasma was measured by HPLC.ResultsThe UV absorption spectrum of the precipitate resembled that of thiopentone. HPLC analysis produced a single peak with the same retention time as thiopentone (4.6 min). In human plasma the solubility of the precipitate was not different from that of thiopentone acid. The solubility of thiopentone was greater than that of the precipitate.ConclusionThe precipitate formed by thiopentone and vecuronium in vitro consisted of thiopentone acid, which was insoluble in human plasma.
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