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Pol. Merkur. Lekarski · Dec 2010
Editorial[Practical applications of recombinant alpha-1-antitrypsin in medicine].
- Jacek Kabziński, Józef Kedziora, and Ireneusz Majsterek.
- The University of Humanities and Economics in Lodz, Poland.
- Pol. Merkur. Lekarski. 2010 Dec 1; 29 (174): 345-50.
AbstractAlpha-1-antytripsin deficiency, human plasma protein belonging to serine proteinase inhibitor, is the underlying reason for causing such diseases as liver cirrhosis or pulmonary emphysema. It has been proven that alpha-1-antytripsin deficiency can be treated with replacement therapy of this protein. Because of the risks associated with the administration to patients with deficiency of alpha-1-antytrypsyny protein fractionated from human plasma, the methods of gaining recombinant alpha-1-antytripsin are still being developed. Methods for the production of alpha-1-antytripsin synthesized using transgenic animals can achieve high performance while maintaining a fully functional protein structure. Obtained in this way, alpha-1-antitrypsin gives hope for the use of replacement therapy on a large scale.
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