• Antimicrob. Agents Chemother. · Sep 2017

    Flucloxacillin Results in Suboptimal Plasma Voriconazole Concentrations.

    • Eline W Muilwijk, Bart G J Dekkers, Stefanie S V Henriet, Paul E Verweij, Bregje Witjes, LashofAstrid M L OudeAMLOSchool for Public Health and Primary Care (Caphri), Department of Medical Microbiology, Maastricht University Medical Center, Maastricht, The Netherlands., Geert H Groeneveld, Johannes van der Hoeven, AlffenaarJan Willem CJWCUniversity of Groningen, University Medical Centre Groningen, Department of Clinical Pharmacy and Pharmacology, Groningen, The Netherlands., RusselFrans G MFGMDepartment of Pharmacology and Toxicology, Radboud university medical center, Nijmegen, The Netherlands., Frank van de Veerdonk, and BrüggemannRoger J MRJMDepartment of Pharmacy, Radboud university medical center, Nijmegen, The Netherlands eline.muilwijk@radboudumc.nl roger.bruggemann@radboudumc.nl.Center of Expertise in Mycology Radboudumc/CWZ and Radboud Institute of Health Science, .
    • Department of Pharmacy, Radboud university medical center, Nijmegen, The Netherlands eline.muilwijk@radboudumc.nl roger.bruggemann@radboudumc.nl.
    • Antimicrob. Agents Chemother. 2017 Sep 1; 61 (9).

    AbstractCombining voriconazole and flucloxacillin is indicated in patient cohorts experiencing both invasive aspergillosis and Gram-positive infections (e.g., patients with chronic granulomatous disease or postinfluenza pulmonary aspergillosis). We report a highly relevant interaction between voriconazole and flucloxacillin, resulting in subtherapeutic plasma voriconazole concentrations in more than 50% of patients, that poses a severe threat if not managed properly.Copyright © 2017 American Society for Microbiology.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…