• Angela Strain.
• University of North Carolina Chapel Hill, 170 Manning Dr. CB# 7594, Chapel Hill, NC 27599-7594, United States of America. Electronic address: angela_strain@med.unc.edu.
• Am J Emerg Med. 2022 Mar 1; 53: 284.e5-284.e6.

BackgroundAngioedema is an allergic reaction that has rarely been associated with haloperidol. There are 3 case reports in the literature, including one involving a child. Angioedema is mediated by increased capillary permeability and plasma extravasation, either related to histamine/IgE or bradykinin. When triggered by a medication, it typically presents within a few hours of medication administration. Histamine-mediated angioedema is generally treated with corticosteroids, antihistamines, and/or epinephrine.Case PresentationWe review a case of angioedema of the tongue in an adolescent, thought to be triggered by haloperidol. Initial treatment was targeted toward a presumed dystonic reaction. Telephone consent was obtained from the patient's mother to publish this report.ConclusionsClinicians should be aware of potential dangerous adverse effects of commonly used medications. Patients with angioedema may need to be monitored for up to 36 h.Copyright © 2021 Elsevier Inc. All rights reserved.

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