• Jung H Kim, Alexander Shustorovich, Aaron T Arel, Sherry A Downie, Steven P Cohen, and Soo Yeon Kim.
• Department of Anesthesiology, Ichan School of Medicine at Mount Sinai West, New York, New York.
• Pain Med. 2022 Jan 3; 23 (1): 144-151.

ObjectiveTo verify the articular branch contributions in the human knee, delineate their anatomical variance, and outline the limitations of currently applied procedure protocols for denervation of the knee joint.DesignA detailed anatomical dissection.SettingCadavers in residence at the Albert Einstein College of Medicine.SubjectsIn total, 24 lower extremity specimens from 14 embalmed cadavers.MethodsHuman cadaveric dissections were performed on 24 lower extremities from 14 embalmed cadavers.ResultsThis cadaveric study has demonstrated that the anterior knee receives sensory innervations from SMGN, SLGN, LRN, NVI, NVL, RFN, and IMGN. The courses of SMGN, SLGN, RFN, and IMGN are similar to recent anatomical studies. However, discrepancies exist in their relative anatomy to bony and radiographic landmarks.ConclusionsGenicular denervation using classical anatomical landmarks may not be sufficient to treat the anterior knee joint pain. Our findings illustrate more accurate anatomic landmarks for the three-target paradigm and support additional targets for more complete genicular denervation. This cadaveric study provides robust anatomical findings that can provide a foundation for new anatomical landmarks and targets to improve genicular denervation outcomes.© The Author(s) 2021. Published by Oxford University Press on behalf of the American Academy of Pain Medicine. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

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