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- Todd J Schwedt, Melissa J Krauss, Karen Frey, and Robert W Gereau.
- Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA. schwedtt@neuro.wustl.edu
- Cephalalgia. 2011 Jan 1;31(1):6-12.
ObjectiveTo determine if migraineurs have evidence of interictal cutaneous sensitisation.Subjects And MethodsThermal and mechanical pain thresholds in 20 episodic migraineurs, 20 chronic migraineurs, and 20 non-migraine control subjects were compared. Quantitative sensory testing was conducted when subjects had been migraine-free for at least 48 h. Heat, cold and mechanical pain thresholds, and heat and cold pain tolerance thresholds were measured.ResultsThermal pain thresholds and thermal pain tolerance thresholds differed significantly by headache group (P = 0.001). During the interictal period, episodic and chronic migraineurs were more sensitive to thermal stimulation than non-migraine controls.ConclusionsInterictal sensitisation may predispose the migraineur to development of headaches, may be a marker of migraine activity, and a target for treatment.
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