• Masayo Sato, Shun Manabe, Mitsuyo Itabashi, Shigeru Horita, Orie Hirose, Moe Kawashima, Miki Nishida, Hiroshi Kataoka, Sekiko Taneda, Toshio Mochizuki, and Kosaku Nitta.
• Department of Nephrology, Tokyo Women's Medical University, Japan.
• Intern. Med. 2022 Apr 15; 61 (8): 120512091205-1209.

AbstractA slowly progressive middle-aged man initially diagnosed with thin basement membrane nephropathy based on extensive thinning of the glomerular basement membrane (GBM) was subsequently diagnosed with Alport syndrome (AS) by a serial renal biopsy eight years later. The ultrastructural analysis of the second biopsy indicated thickening and wrinkling with mild reticulation in the GBM, consistent with AS. However, a retrospective analysis of the first biopsy revealed mild attenuation of type IV collagen α5 chain staining, suggesting a potential diagnosis of AS, despite the lack of ultrastructural features of AS. We herein report the clinical usefulness of type IV collagen staining in the early diagnosis of AS.

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