• Neuroscience letters · Jul 2008

    Tx3-4 a toxin from the venom of spider Phoneutria nigriventer blocks calcium channels associated with exocytosis.

    • Célio José de Castro Junior, Ana Cristina N Pinheiro, Cristina Guatimosim, Marta N Cordeiro, Alessandra H Souza, Michael Richardson, Marco A Romano-Silva, Marco Antônio M Prado, and Marcus V Gomez.
    • Departamento Farmacologia BeloHorizonte, MG, Brazil. celiojcjunior@yahoo.com.br
    • Neurosci. Lett. 2008 Jul 11;439(2):170-2.

    AbstractThe purpose of the present work was to investigate the pharmacological action of a calcium channel-blocking toxin from the venom of the spider Phonetic nigriventer, Tx3-4 on calcium channels coupled to exocytosis of synaptic vesicles. Tx3-4 blocked KCl-induced exocytosis of synaptic vesicles with an IC50 of 1.1 nM. To investigate whether the target of Tx3-4 overlaps with known calcium channels that mediate calcium entry and exocytosis, we used omega-toxins that interact selectively with neuronal calcium channels. The results indicate that the main population of voltage-sensitive calcium channels altered by Tx3-4 is P/Q calcium channels. In conclusion, Tx3-4 is a potent inhibitor of calcium channels involved in the KCl-induced exocytosis of synaptic vesicles in brain cortical synaptosomes.

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