• F Hansmann, A Kramer, H Ohgke, H Strobel, M Müller, and G Geerling.
• Klinik für Augenheilkunde, Campus Lübeck des Universitätsklinikums Schleswig-Holstein, Lübeck. hansmann@t-online.de
• Ophthalmologe. 2005 Nov 1; 102 (11): 1043-6, 1048-50.

BackgroundTo reduce the risk of endophthalmitis PVP-iodine is typically used preoperatively. Since iodine is contraindicated in patients with a specific allergic history or severe thyroid disorder we studied the effect of Lavasept, which contains Polyhexanid as an antiseptic alternative.Patients And MethodsIn a randomized controlled double-blind trial 3 drops of 0.2% Lavasept, 1.25% PVP-iodine or Ringer's solution were applied preoperatively to 67 patients, which have had a minimum of 5 colony forming units (cfu's) in the conjunctival swap. The effectiveness and tolerability were measured.ResultsAfter application of Lavasept or PVP-iodine, the number of cfu was statistically significantly reduced. Lavasept reduced the number of bacterial colonies significantly better than PVP-iodine (p=0.05). All test solutions were equally well tolerated.ConclusionThe use af Lavasept is safe, well tolerated and reduces the microbiological contamination of the conjunctival fornix effectively. lt provides a more effective reduction of the cfu's than PVP-iodine 1.25% and this effect tends to be prolonged. Lavasept is a good alternative option in ophthalmology for preoperative antisepsis.

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