• Whitney Wolaver, Shilen Thakrar, Kelvin Thomas, Hiral Thakrar, Lawrence Schwartz, Wilhelm Zuelzer, John Butterworth, and Kyle Hoelting.
• Department of Anesthesiology, Virginia Commonwealth University Health System, Richmond, Virginia.
• Curr Opin Anaesthesiol. 2021 Dec 1; 34 (6): 761765761-765.

Purpose Of Reviewα-Gal syndrome is among a vexing perioperative consideration for anesthesiologists. Commonly referred to as 'red meat allergy', α-Gal syndrome is precipitated by a lone star tick bite resulting in the formation of immunoglobulin E (IgE) antibodies against the tick salivary glycoproteins and noncatarrhine mammalian tissue.Recent FindingsUp to 20% of the population in the southeastern United States may test positive for IgE antibodies to α-Gal. Increasingly, recognition of α-Gal syndrome as an immune response to red meat consumption and certain drugs, many of which may be administered within the perioperative period, has led to greater awareness of the insidious nature of its presentation - from mild urticaria and gastrointestinal symptoms to severe anaphylaxis.SummaryWith the increasing prevalence and identification of α-Gal syndrome, a safe and tailored perioperative process is needed to integrate a pathway that involves multidisciplinary communication, robust information sharing platform, and a structured peri-procedure management.Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.

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