• J Palliat Med · Jul 2008

    Case Reports

    Myoclonus associated with high-dose parenteral methadone.

    • Shiho Ito and Solomon Liao.
    • VITAS Innovative Hospice Care, Orange County, Orange, California, USA.
    • J Palliat Med. 2008 Jul 1;11(6):838-41.

    AbstractMethadone is generally believed to be devoid of neuroexcitatory properties, and its use is increasing. This paper reports two cases of myoclonus with high-dose parenteral methadone in patients with cancer under hospice care. This side effect may be dose related and/or due to the parenteral route of administration. Reduction of the dose and change of route was sufficient to eliminate the myoclonus while maintaining an adequate pain control. Possible mechanisms for methadone causing myoclonus include a redistribution of receptor saturation in the N-methyl-D-aspartate (NMDA) and delta receptors. Ketamine may be an option for patients with intractable pain who develop methadone-induced myoclonus.

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