[Aspirin in primary prevention of cardiovascular and

Dtsch. Med. Wochenschr. · Oct 2021

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[Aspirin in primary prevention of cardiovascular and cerebrovascular diseases].

Acetylsalicylic acid (aspirin) is one of the most used medications worldwide. The antithrombotic agent acts mainly through inhibition of cyclooxygenase-1 and consequently thromboxane A2 synthesis, causing an irreversible suppression of platelet function. Despite of its proven benefit in the treatment and secondary prevention of atherosclerotic diseases, its use for the primary prevention remains controversial due to an unclear balance between the benefits and risks of aspirin. Moreover, the recent evidence indicates that the risk of major bleeding outweighs the potential to reduce ischemic events in patients without atherosclerotic diseases, thus, precluding the general use of aspirin for the primary prevention.

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- Natig Gassanov, Martin Eicke, and Fikret Er.
- Medizinische Klinik II, Klinikum Idar-Oberstein, Idar-Oberstein.
- Dtsch. Med. Wochenschr. 2021 Oct 1; 146 (20): 1353-1359.
AbstractAcetylsalicylic acid (aspirin) is one of the most used medications worldwide. The antithrombotic agent acts mainly through inhibition of cyclooxygenase-1 and consequently thromboxane A2 synthesis, causing an irreversible suppression of platelet function. Despite of its proven benefit in the treatment and secondary prevention of atherosclerotic diseases, its use for the primary prevention remains controversial due to an unclear balance between the benefits and risks of aspirin. Moreover, the recent evidence indicates that the risk of major bleeding outweighs the potential to reduce ischemic events in patients without atherosclerotic diseases, thus, precluding the general use of aspirin for the primary prevention.Thieme. All rights reserved.

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[Aspirin in primary prevention of cardiovascular and cerebrovascular diseases].

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