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- S V Popov, R G Guseinov, O N Skryabin, I N Orlov, and A G Martov.
- St. Lukes Clinical Hospital, St. Petersburg, Russia.
- Urologiia. 2018 Jul 1 (3): 92-97.
AbstractCurrently, prostate biopsy remains the main method used to diagnose prostate cancer (PCa). The indication for the procedure is an elevated level of the serum level of the total prostate-specific antigen (PSA). However, the PSA test is organ- but not cancer-specific, and patients may undergo an unnecessary biopsy, which is an invasive procedure associated with a risk of complications. Additional tests have been developed aimed to improve the diagnostic performance of PSA for detecting PCa. They include PSA derivatives such as free PSA fraction, -2proPSA, PSA density, PHI and the free /total PSA fraction.
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