• Jozef Babala, Petra Zahradníková, Igor Béder, Lenka Fedorová, Martin Lindák, Ľudmila Košťálová, Zuzana Pribilincová, Juraj Staník, and Róbert Králik.
• Department of Pediatric Surgery, Faculty of Medicine, Comenius University in Bratislava, National Institute of Children's Diseases, Bratislava, Slovakia. Electronic address: jozef.babala@gmail.com.
• Int. J. Pediatr. Otorhinolaryngol. 2019 Dec 1; 127: 109673.

IntroductionThyroid cancer in children is a hot topic because of the large clinical heterogeneity and the risk of severe complications. We aimed to study 1. The frequency, 2. Etiology, and 3. Risk factors of post-surgery complications of thyroid cancer.Material And MethodsA retrospective analysis including risk factors for post-surgery complications of patients treated for thyroid malignancies in years 2006-2018 was performed.ResultsOver a period of 12 years 22 patients with thyroid malignancy (68% female; 12.6 ± 4.0 years of age, median follow-up 6 years) were identified. Histologically, 12 (55%) patients had papillary carcinoma. Six patients (27.3%) had multiple endocrine neoplasia type 2 (MEN2) syndrome, 3 (13.7%) patients had medullary carcinoma and 1 patient had follicular carcinoma. Neck lymph node metastases were diagnosed in 8 (36.4%), distant metastases in 6 (27.3%), and both locations were involved in 4 (18.2%) patients. Six (27.3%) children had surgical complications: 1 child had unilateral vocal cord paralysis and transient hypoparathyroidism and 5 had transient hypoparathyroidism. The higher risk of surgery complications in forward stepwise logistic regression was associated in with distant metastases (R2 = 0.584, OR 52.63, p = 0.010).ConclusionsPostoperative complications were significantly associated with presence of distant metastases. Favorable results were observed in with children with MEN2 syndrome.Copyright © 2019 Elsevier B.V. All rights reserved.

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