• Matthias A Mutke, Vince I Madai, Federico C von Samson-Himmelstjerna, Olivier Zaro Weber, Gajanan S Revankar, Steve Z Martin, Katharina L Stengl, Miriam Bauer, Stefan Hetzer, GüntherMatthiasMFraunhofer/MEVIS, Bremen, Germany., and Jan Sobesky.
• Center for Stroke Research, Charité Universitätsmedizin, Berlin, Germany ; Department of Neurology, Charité Universitätsmedizin, Berlin, Germany.
• Plos One. 2014 Jan 1; 9 (2): e87143.

IntroductionIn brain perfusion imaging, arterial spin labeling (ASL) is a noninvasive alternative to dynamic susceptibility contrast-magnetic resonance imaging (DSC-MRI). For clinical imaging, only product sequences can be used. We therefore analyzed the performance of a product sequence (PICORE-PASL) included in an MRI software-package compared with DSC-MRI in patients with steno-occlusion of the MCA or ICA >70%.MethodsImages were acquired on a 3T MRI system and qualitatively analyzed by 3 raters. For a quantitative analysis, cortical ROIs were placed in co-registered ASL and DSC images. Pooled data for ASL-cerebral blood flow (CBF) and DSC-CBF were analyzed by Spearman's correlation and the Bland-Altman (BA)-plot.ResultsIn 28 patients, 11 ASL studies were uninterpretable due to patient motion. Of the remaining patients, 71% showed signs of delayed tracer arrival. A weak correlation for DSC-relCBF vs ASL-relCBF (r = 0.24) and a large spread of values in the BA-plot owing to unreliable CBF-measurement was found.ConclusionThe PICORE ASL product sequence is sensitive for estimation of delayed tracer arrival, but cannot be recommended to measure CBF in steno-occlusive disease. ASL-sequences that are less sensitive to patient motion and correcting for delayed blood flow should be available in the clinical setting.

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