• Yu-Juan Xu, Jason Chia-Hsien Cheng, Jang-Ming Lee, Pei-Ming Huang, Guan-Hua Huang, and Cheryl Chia-Hui Chen.
• School of Nursing and Graduate Institute of Oncology, National Taiwan University, Taipei, Taiwan, Republic of China; Division of Radiation Oncology, Department of Oncology, and Division of Thoracic Surgery, Department of Surgery, National Taiwan University and National Taiwan University Hospital, Taipei, Taiwan, Republic of China; Institute of Statistics, National Chiao Tung University, Hsinchu, Taiwan, Republic of China.
• Oncologist. 2015 Oct 1; 20 (10): 1216-22.

BackgroundPreserving functional walking capacity and nutritional status is important for patients with esophageal cancer, but no effective intervention is available, particularly during active treatment.MethodsThis pilot randomized controlled trial tested the effects of a walk-and-eat intervention for patients with esophageal cancer undergoing neoadjuvant chemoradiotherapy. Participants with locally advanced esophageal cancer stage IIB or higher (n = 59) were randomly assigned to receive the walk-and-eat intervention (n = 30; nurse-supervised walking three times per week and weekly nutritional advice) or usual care (n = 29; control group) during 4-5 weeks of chemoradiotherapy. Primary endpoints were changes in distance on the 6-minute walk test, hand-grip strength, lean muscle mass, and body weight between initiation and completion of intervention.ResultsParticipants (mean age: 59.6 years) were mostly male (92.9%) with squamous cell carcinoma (96.4%). During chemoradiotherapy, participants who received the walk-and-eat intervention had 100-m less decline than controls in walk distance (adjusted p = .012), 3-kg less decrease in hand-grip strength (adjusted p = .002), and 2.7-kg less reduction in body weight (adjusted p < .001), regardless of age. The intervention group also had significantly lower rates of need for intravenous nutritional support and wheelchair use.ConclusionThe nurse-led walk-and-eat intervention is feasible and effective to preserve functional walking capacity and nutritional status for patients with esophageal cancer undergoing neoadjuvant chemoradiotherapy.©AlphaMed Press.

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