• A Vallée, A Chan-Hew-Wai, B Bonan, P Lesprit, F Parquin, É Catherinot, J Choucair, D Billard, C Amiel-Taieb, È Camps, C Cerf, D Zucman, and E Fourn.
• Department of Clinical Research and Innovation, Foch Hospital, Suresnes, France. Electronic address: alexandre.g.vallee@gmail.com.
• Public Health. 2021 Jul 1; 196: 135-137.

ObjectivesA strong COVID-19 vaccine campaign is needed to reach the herd immunity and reduce this pandemic infection.Study DesignIn the Foch Hospital, France, in February 2021, 451 healthcare workers were vaccinated by a first dose of AstraZeneca vaccine.MethodsAdverse effects were reported to our pharmaco-vigilance circuit, by an online and anonymous questionnaire following the first weeks of the vaccinal campaign to healthcare workers.ResultsTwo hundred seventy-four (60.8%) of them reported multiple adverse effects. Main adverse effects reported were feverish state/chills (65.7%), fatigue/physical discomfort (62.4%), arthralgia/muscle pain (61.0%) and fever (44.5%).ConclusionsOn March 2021 many European countries suspended AstraZeneca vaccine for one week due to safety uncertainty. Thus, confidence in its efficacy is undermined. However, the benefit/risk balance is clearly in favor of vaccination.Copyright © 2021 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved.

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