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- D M Simpson, J-M Gracies, H K Graham, J M Miyasaki, M Naumann, B Russman, L L Simpson, Y So, and Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology.
- Department of Neurology, Mount Sinai Medical Center, New York, NY, USA.
- Neurology. 2008 May 6;70(19):1691-8.
ObjectiveTo perform an evidence-based review of the safety and efficacy of botulinum neurotoxin (BoNT) in the treatment of adult and childhood spasticity.MethodsA literature search was performed including MEDLINE and Current Contents for therapeutic articles relevant to BoNT and spasticity. Authors reviewed, abstracted, and classified articles based on American Academy of Neurology criteria (Class I-IV).ResultsThe highest quality literature available for the respective indications was as follows: adult spasticity (14 Class I studies); spastic equinus and adductor spasticity in pediatric cerebral palsy (six Class I studies).RecommendationsBotulinum neurotoxin should be offered as a treatment option for the treatment of spasticity in adults and children (Level A).
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