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Case Reports
Bone marrow abnormalities in HIV infected children, report of three cases and review of the literature.
- Ira Shah and Anuradha Murthy.
- Pediatric HIV Clinic, B. J. Wadia Hospital for Children, Mumbai, Maharashtra, India.
- J Res Med Sci. 2014 Feb 1; 19 (2): 181-3.
AbstractBone marrow abnormalities in HIV infected adults include hypocellularity, myelodysplasia and poor marrow recovery. Data in children is limited. We report a series of three HIV infected with varied bone marrow abnormalities. First child was a 7-year-old boy with pulmonary tuberculosis, anemia, thrombocytopenia and bone marrow examination showed hypoplastic marrow. He succumbed to his disease within seven days of hospitalization. Second child was a three and a half year old girl who had severe anemia and her bone marrow examination showed dyserythropoiesis. Third child was a 7-year-old boy who had splenic abscesses and pancytopenia and bone marrow examination showed myelofibrosis with increased plasma cells. He also succumbed due to a fatal pulmonary bleed. Thus, advanced HIV disease in children can lead to bone marrow suppression in form of hypoplasia or myelofibrosis which can be fatal.
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