• Ana Pejcic, Vidojko Djordjevic, Draginja Kojovic, Vesna Zivkovic, Ivan Minic, Dimitrije Mirkovic, and Mariola Stojanovic.
• Department of Periodontology and Oral Medicine, Medical Faculty, University of Nis, Nis, Serbia.
• Med Princ Pract. 2014 Jan 1; 23 (2): 149-53.

ObjectiveTo evaluate the effect of periodontal treatment on gingival overgrowth in a group of renal transplant patients.Subjects And MethodsTwenty-five renal transplant recipients receiving immunosuppressive therapy with cyclosporine A (CsA) were randomly assigned to 2 groups. Group 1 (n = 15) included patients who had been specifically referred to a dental clinic to prevent gingival overgrowth and were given full periodontal therapy. Group 2 (n = 10) was comprised of patients who did not receive any professional periodontal cleaning. Patients from both groups were examined to determine their periodontal status before and after 3, 6 and 12 months in terms of their plaque index, gingival index and gingival overgrowth. During the examination, their overall health was stable.ResultsFor group 1, the scores were 1.89 (baseline), 0.98 (6 months) and 0.56 (12 months), and hence there were significant reductions (p = 0.0001). The gingival indices were 1.71 (baseline), 0.76 (6 months) and 0.35 (12 months), and the reductions were also significant (p = 0.0001). A significant association was observed between poor oral hygiene and the degree of gingival overgrowth. The 1-year post-treatment follow-up showed that patients in group 1 did not develop gingival overgrowth due to the use of CsA as group 2 did without prior periodontal therapy.ConclusionOral hygiene status was the most important variable related to the development and degree of gingival overgrowth due to the use of CsA.© 2013 S. Karger AG, Basel.

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