• Ehsan Bahrami, Parisa Mirmoghtadaee, Gelayol Ardalan, Hamid Zarkesh-Esfahani, Mohammad Hassan Tajaddini, Shaghayegh Haghjooy-Javanmard, Hananeh Najafi, and Roya Kelishadi.
• Department of Immunology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
• J Res Med Sci. 2014 May 1; 19 (5): 387-90.

BackgroundIn this study, we aim to compare insulin and leptin levels in adolescents with or without excess weight and in those with or without abdominal obesity.Materials And MethodsThis case-control study was conducted among 486 samples. We randomly selected 243 overweight and an equal number of normal-weight adolescents from among participants of the third survey of a national surveillance program entitled Childhood and Adolescence Surveillance and PreventIon of Adult Non-communicable diseases study. Serum insulin and leptin were compared between two groups and their correlation was determined with other variables.ResultsThe mean age and body mass index (BMI) of participants were 14.10 ± 2.82 years and 22.12 ± 6.49 kg/m(2), respectively. Leptin and insulin levels were higher in overweight than in normal-weight adolescents (P < 0.05). Leptin level was higher in children with abdominal obesity than in their other counterparts (P < 0.001). Leptin level was correlated with age, fasting blood glucose, BMI, and insulin level.ConclusionInsulin and leptin levels were higher among overweight and obese children, which may reflect insulin and leptin-resistance. Given the complications of excess weight from early life, prevention and controlling childhood obesity should be considered as a health priority.

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