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- Yung-Sung Yeh, Meng-Lin Huang, Se-Fen Chang, Chin-Fan Chen, Huang-Ming Hu, and Jaw-Yuan Wang.
- Department of Emergency Medicine, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung, Taiwan, ROC.
- Med Princ Pract. 2014 Jan 1; 23 (5): 478-81.
ObjectiveTo report a metastatic colorectal cancer patient with hyperbilirubinemia treated with a combination of bevacizumab and FOLFIRI (5-fluorouracil, leucovorin, and irinotecan) using uridine diphosphate glucuronosyl transferase (UGT1A1) genotyping.Clinical Presentation And InterventionA 46-year-old male was diagnosed with rectosigmoid colon cancer with liver metastases and hyperbilirubinemia presenting with severe jaundice. UGT1A1 genotyping was used before therapy to ascertain whether genotype-adjusted dosages of irinotecan plus bevacizumab could alleviate the toxicity. Then, the patient was treated with FOLFIRI.ConclusionThe FOLFIRI regimen was successfully used in this patient without concerns regarding toxicity.© 2014 S. Karger AG, Basel.
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