• Alper Bugra Nacar, Ali Erayman, Mustafa Kurt, Eyup Buyukkaya, Mehmet Fatih Karakaş, Adnan Burak Akcay, Sule Buyukkaya, and Nihat Sen.
• Department of Cardiology, School of Medicine, Mustafa Kemal University, Hatay, Turkey.
• Med Princ Pract. 2015 Jan 1; 24 (1): 65-9.

ObjectivesTo investigate the relationship between neutrophil/lymphocyte ratio (NLR) and coronary collateral circulation (CCC) in patients with coronary chronic total occlusion.Subjects And MethodsOur study population consisted of 275 consecutive patients with chronic total occlusion. One hundred and thirty-eight patients with chronic total occlusion were included in the study. They were classified into 2 groups as follows: impaired CCC (group 1: Rentrop grades 0-1) and good CCC (group 2: Rentrop grades 2-3). The NLR was calculated from the complete blood count.ResultsThe NLR values of the patients with impaired CCC (4.5 ± 0.7) were significantly higher than of those with good CCC (2.7 ± 0.6, p < 0.001). In the multivariate logistic regression test, NLR (OR 33.36, 95% CI 8.189-135.7, p < 0.001), high-sensitivity C-reactive protein (hs-CRP; OR 2.152, 95% CI 1.226-3.777, p = 0.008), estimated glomerular filtration rate (OR 1.167, 95% CI 1.049-1.298, p = 0.004) and systolic blood pressure (OR 1.068, 95% CI 1.009-1.1310, p = 0.025) were independent predictors of impaired CCC. The NLR value >3.55 yielded an area under the curve value of 0.957 (95% CI 0.921-0.992, p < 0.001) and demonstrated a sensitivity of 95% and a specificity of 90% for the prediction of CCC. A moderate correlation between NLR and hs-CRP was observed (r = 0.443; p < 0.001).ConclusionOur findings reveal that NLR correlates with the impaired development of coronary collaterals.© 2014 S. Karger AG, Basel.

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