• Deborah R Kim, Liisa Hantsoo, Michael E Thase, Mary Sammel, and C Neill Epperson.
• 1 Penn Center for Women's Behavioral Wellness, Perelman School of Medicine at the University of Pennsylvania , Philadelphia, Pennsylvania.
• J Womens Health (Larchmt). 2014 Oct 1; 23 (10): 842-8.

BackgroundPregnant women with major depressive disorder (MDD) report that psychotherapy is a more acceptable treatment than pharmacotherapy. However, although results of several studies suggest that psychotherapy is an effective treatment for pregnant women, logistical barriers-including cost and traveling for weekly visits-can limit real-world utility. We hypothesized that computer-assisted cognitive behavior therapy (CCBT) would be both acceptable and would significantly decrease depressive symptoms in pregnant women with MDD.MethodsAs a preliminary test of this hypothesis, we treated 10 pregnant women with MDD using a standardized CCBT protocol.ResultsThe pilot results were very promising, with 80% of participants showing treatment response and 60% showing remission after only eight sessions of CCBT.ConclusionA larger, randomized controlled trial of CCBT in pregnant women with MDD is warranted.

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