• Medicina clinica · Jun 2022

    Meta Analysis

    The effects of resveratrol on glycemic control and cardiometabolic parameters in patients with T2DM: A systematic review and meta-analysis.

    • Ibrahim A Abdelhaleem, Aml M Brakat, Hoda M Adayel, Moamen M Asla, Marwa A Rizk, and Aya Y Aboalfetoh.
    • Faculty of Medicine, Zagazig University, Zagazig City, Sharkia 44519, Egypt; International Medical Research Association IMedRA, Egypt. Electronic address: Ibrahim265862@medicine.zu.edu.eg.
    • Med Clin (Barc). 2022 Jun 24; 158 (12): 576-585.

    BackgroundType 2 diabetes mellitus (T2DM) is a progressive meta-inflammatory disorder, which induce micro and macrovascular complications. Resveratrol is a nutraceutical known to have antioxidant and anti-inflammatory properties. It improves insulin resistance; however, no clear evidence regarding its effects in patients with T2DM.ObjectivesWe aimed to evaluate the efficacy and the safety of oral resveratrol supplementation in type 2 diabetic patients concerning dose and duration.MethodsWe searched PubMed, Cochrane Library, Scopus, WOS, Wiley, and Google Scholar for RCTs evaluating the efficacy and safety of resveratrol on patients with T2DM. We screened the studies for the eligibility criteria, performed the quality assessment, extracted the studies' characteristics, baseline, and outcome data of interest, and finally conducted the meta-analysis using RevManV5.3.ResultsThis systematic review and meta-analysis, including 17 RCTs with total 871 patients with T2DM, showed that resveratrol was superior to placebo on fasting blood glucose (FBG) and total cholesterol (TC) with doses ≥500mg {MD=-13.34, 95%CI [-22.73, -3.95], P=0.005}, {MD=-5.64, 95%CI [-6.95, -4.33], P<0.00001} respectively. Moreover, it improved HbA1c at three months {MD=-0.41, 95%CI [-0.65, -0.16], P=0.001 and systolic blood pressure {MD: -7.91, 95%CI [-10.44, -5.37], P<0.00001}.ConclusionWe concluded that resveratrol beneficially modulates glycemic control as well as cardiometabolic parameters in patients with T2DM.Copyright © 2021 Elsevier España, S.L.U. All rights reserved.

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