• Declan T Barry, Corey Pilver, Marc N Potenza, and Rani A Desai.
• Department of Psychiatry, Yale University School of Medicine, USA. declan.barry@yale.edu
• J Psychiatr Res. 2012 Jan 1; 46 (1): 118-27.

ObjectiveTo examine gender differences in the associations of levels of pain interference and psychiatric disorders among a nationally representative sample of adult men and women.MethodChi-square tests and multinomial logistic regression analyses were performed on data obtained from the National Epidemiologic Survey on Alcohol and Related Conditions from 42,750 adult respondents (48% men; 52% women), who were categorized according to three levels of pain interference (i.e., no or low pain interference [NPI], moderate pain interference [MPI], severe pain interference [SPI]).ResultsFemale respondents in comparison to male respondents were more likely to exhibit moderate (p < 0.001) or severe pain interference (p < 0.001). Levels of pain interference were associated with past-year Axis I and lifetime Axis II psychiatric disorders in both male and female respondents (p < 0.05), with the largest odds typically observed in association with moderate or severe pain interference. A stronger relationship between MPI and alcohol abuse or dependence (OR = 1.61, p < 0.05) was observed in male participants as compared to female ones, while a stronger relationship between SPI and drug abuse or dependence (OR = 0.57, p < 0.05) was observed in female respondents as compared to male ones.ConclusionsLevels of pain interference are associated with the prevalence of Axis I and Axis II psychiatric disorders in both men and women. Differences in the patterns of co-occurring substance-related disorders between levels of pain interference in male and female respondents indicate the importance of considering gender-related factors associated with levels of pain interference in developing improved mental health prevention and treatment strategies.Copyright © 2011 Elsevier Ltd. All rights reserved.

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