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- K Herrlinger, K Fellermann, and E F Stange.
- Abteilung Innere Medizin 1, Asklepios Klinik Nord, Standort Heidberg, Tangstedter Landstr. 400, 22417, Hamburg, Deutschland, k.herrlinger@asklepios.com.
- Internist (Berl). 2014 Aug 1; 55 (8): 906-17.
AbstractCrohn's disease and ulcerative colitis are the most common forms of chronic inflammatory bowel disease. The therapeutic algorithm is complex and individualized especially in complicated courses of the disease. This article gives a comprehensive overview on the typical courses of disease and the standard therapy of both diseases. Furthermore, ongoing controversies will be highlighted including early immunosuppression and immunomodulation as well as new therapeutic goals, such as mucosal healing. Finally, a perspective on future therapeutic options is given focusing especially on vedolizumab, the new antibody against the bowel-specific α4β7-integrin.
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