• Mitra Jabalameli and Forough Kalantari.
• Anesthesia and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
• Adv Biomed Res. 2014 Jan 1; 3: 197.

BackgroundInadequate pain control has a significant role in maternal and neonatal health in early post-partum period which interferes with breastfeeding and has a negative influence on child normal growth. The aim of this study is evaluation of subcutaneous methadone effectiveness on post-operative pain control.Materials And MethodsDouble blind randomized prospective clinical trial involving 60 term pregnancy patients through 2008 to 2009 Undergo cesarean.Inclusion CriteriaPrime gravid candidate of elective cesarean and spinal anesthesia class 1 or 2. Known case of drug allergy and methadone interaction, addiction, uncontrolled medical disease excluded. Case group injected 10 mg of subcutaneous methadone in the site of incision before final suture. Morphine was a pain reliever in follow up examination. Data include mean of pain, nausea and vomiting, MAP, etc., collected and analyzed by independent-T test and Man Whitney test.ResultsAlthough mean usage of morphine between groups was not significant statistically but the mean pain severity (P value < 0.05) and mean satisfactory (P value = 0.02) was statistically significant between groups. Other parameters were not statistically significant.ConclusionWe suggest subcutaneous methadone as a safe pain reliever in post cesarean section patients.

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