• Emine Binnetoğlu, Mehmet Asik, Burak Altun, Hacer Sen, Emine Gazi, Gökhan Erbağ, Fahri Günes, Yıldız Garip Bilen, Ahmet Temiz, Ahmet Barutçu, and Adem Bekler.
• Department of Internal Medicine, Faculty of Medicine, Çanakkale Onsekiz Mart University, Kepez, Çanakkale, Turkey, edemirbas1@yahoo.com.
• Wien. Klin. Wochenschr. 2014 Aug 1; 126 (15-16): 485-90.

BackgroundThyroid hormones have several effects on the cardiovascular system, and recent studies have found that thyroid disorders affect coronary intima-media thickness (CIMT) in particular. Despite increased CIMT in patients with hyperthyroidism, the extent of the relationship between CIMT and epicardial fat thickness (EFT) in those patients is unknown. Furthermore, there is no report evaluating the relationship between EFT and overt hyperthyroidism (OH) in the literature. In this study, we aim to evaluate the effectiveness of EFT in predicting atherosclerosis as well as CIMT in patients with OH.MethodsA total of 30 newly diagnosed, untreated overt hyperthyroid patients and 44 control subjects were included in the study. EFT was measured using a commercially available echocardiography machine (VIVID 7; General Electric Medical Systems, Norway) with a 2.5-MHz probe. The echo-free space between the visceral and parietal pericardium on the anterior wall of the right ventricle was diagnosed as EFT. A linear-array imaging probe of the same echocardiography probe was used to evaluate the CIMT of the right common carotid artery.ResultsThe hyperthyroid patients had a significantly greater EFT (mean: 4.31 ± 1.12 mm) than the healthy subjects (mean: 3.11 ± 0.84 mm; p < 0.001). CIMT was also significantly greater in the hyperthyroid patients (mean: 0.62 ± 0.17 mm) than in the healthy subjects (mean: 0.50 ± 0.11 mm; p < 0.01).ConclusionIn conclusion, the present study shows that mean EFT and CIMT were significantly higher in OH patients, irrespective of confounding factors such as hypertension.

20 keywords...

hide…