• Jiseun Lim, Yeong-Jun Song, Woong-Sub Park, Haesook Sohn, Moo-Sik Lee, Dong-Hoon Shin, Chun-Bae Kim, Hwasung Kim, Gyung-Jae Oh, and Moran Ki.
• Department of Preventive Medicine, Eulji University School of Medicine, 77 Gyeryong-ro 771beon-gil, Jung-gu, Daejeon 301-808, Korea. moranki@naver.com.
• Yonsei Med. J. 2014 Jan 1; 55 (1): 126-31.

PurposeAssessing the immunogenicity of a single dose of hepatitis A virus (HAV) vaccines is important because some people receive only a single dose. However, previous studies have shown variable results and have not examined the effects of demographic characteristics other than gender. This study was performed to examine the immunogenicity of a single dose of HAV vaccine according to the vaccine type and demographic characteristics in young adults.Materials And MethodsSeronegative medical school students were randomly allocated to receive either Havrix or Epaxal.ResultsAfter approximately 11 months, the seroconversion rate in 451 participants was 80.7%. In men, the Havrix group showed a significantly higher seroconversion rate (81.9%) than the Epaxal group (69.2%), whereas both vaccine groups showed similarly high immunogenicity in women (Havrix: 90.1%, Epaxal: 92.9%; P for interaction=0.062). According to the results of a multivariate analysis, Epaxal showed significantly lower immunogenicity than Havrix only in men. Age, obesity, drinking, smoking, and follow-up time did not significantly affect seroconversion in either gender.ConclusionThe seroconversion rate of single-dose HAV vaccines was low in men, particularly in those who received Epaxal. Our results suggest that gender effects should be considered when comparing the immunogenicity of different HAV vaccines.

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