A severe case of esophageal ulcer causing a tight stricture

Wien. Klin. Wochenschr. · Dec 2014

A severe case of esophageal ulcer causing a tight stricture despite long-term D-penicillamine treatment.

D-penicillamine has long been used in the management of rheumatic diseases due to the effects on inhibition of collagen synthesis. Herein, we report a severe case of esophageal ulcer causing a tight stricture extending through the distal esophagus despite the long-term D-penicillamine treatment in a patient with Wilson's disease. D-penicillamine would theoretically be expected to contribute to the healing of an esophageal ulcer. However, the drug failed to have a favorable outcome, which is notable and worth reporting.

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- Suna Yapali, Ilker Turan, Omer Ozutemiz, and Oktay Tekesin.
- Division of Gastroenterology, Department of Internal Medicine, Ege University School of Medicine, 35100, Izmir, Turkey, sunayapali@yahoo.com.
- Wien. Klin. Wochenschr. 2014 Dec 1; 126 (23-24): 789-91.
AbstractD-penicillamine has long been used in the management of rheumatic diseases due to the effects on inhibition of collagen synthesis. Herein, we report a severe case of esophageal ulcer causing a tight stricture extending through the distal esophagus despite the long-term D-penicillamine treatment in a patient with Wilson's disease. D-penicillamine would theoretically be expected to contribute to the healing of an esophageal ulcer. However, the drug failed to have a favorable outcome, which is notable and worth reporting.

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A severe case of esophageal ulcer causing a tight stricture despite long-term D-penicillamine treatment.

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