• Yu-Quan He, Ya-Nan Zhao, Jin-Ming Zhu, Meng-Chao Zhang, Lin Liu, Hong Zeng, and Ping Yang.
• Division of Cardiology (Y-QH, Y-NZ, J-MZ, HZ, PY); and Division of Radiology (M-CZ, LL), China-Japan Union Hospital of Jilin University, Changchun, Jilin, China.
• Medicine (Baltimore). 2014 Oct 1; 93 (15): e82.

AbstractIdiopathic hypereosinophilic syndrome (IHES) is a rare disease that is frequently associated with cardiac thrombosis and endocardial wall thickness. This case report describes 2 patients who had IHES associated with left ventricular (LV) thrombi. The patients' symptoms are atypical. Peripheral blood and bone marrow tests showed markedly elevated eosinophils. Electrocardiography showed ischemic changes in both patients. Negative computed tomography (CT) angiography excluded coronary artery stenosis. Transthoracic echocardiography (TTE), conventional multislice spiral CT, gemstone spectral CT, and cardiac magnetic resonance imaging were used to identify the LV intraluminal thrombus and endocardial thickening, and the diagnostic values of each imaging method were analyzed and compared. These patients were clinically diagnosed as "IHES, LV thrombosis, NYHA heart function classification I." Both patients received oral prednisone and warfarin therapy. At 5 month follow-up, TTE rechecks showed that the size of the LV thrombotic lesion was reduced in the first case but substantially increased in the second case.

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