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Yonsei medical journal · May 2014
Ibuprofen associated acute vanishing bile duct syndrome and toxic epidermal necrolysis in an infant.
- Hye-young Kim, Hea Kyoung Yang, Seong Heon Kim, and Jae Hong Park.
- Department of Pediatrics, Pusan National University School of Medicine, Yangsan, Korea. ; Medical Research Institute, Pusan National University Hospital, Busan, Korea.
- Yonsei Med. J. 2014 May 1; 55 (3): 834-7.
AbstractAcute vanishing bile duct syndrome, a rare but rapidly progressive destruction of the intrahepatic bile ducts with unknown pathogenesis, is most often a drug- or toxin-related. Toxic epidermal necrolysis is a serious dermatologic condition and a potentially life threatening disease, which is drug or infection induced. Ibuprofen associated acute vanishing bile duct syndrome and toxic epidermal necrolysis have not been reported previously in infants. We report a 7-month-old infant with ibuprofen associated toxic epidermal necrolysis, followed by severe and rapidly progressive vanishing bile duct syndrome. She recovered totally with supportive care.
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