• Jung Hye Hwang, Jeong Wook Kim, Ji Young Hwang, Kyung Min Lee, Hye Min Shim, Young Kyung Bae, Seung Sam Paik, and Hosun Park.
• Department of Obstetrics and Gynecology, College of Medicine, Hanyang University, Seoul, Korea.
• Yonsei Med. J. 2014 Nov 1; 55 (6): 1562-7.

PurposeThis study investigated the possible relationship between viral infection and first trimester pregnancy loss.Materials And MethodsA prospective study was performed on 51 gravidas with missed abortion, fetal anomaly, pre-term delivery, and full-tem delivery at Hanyang University Hospital. Enteroviruses were detected by semi-nested reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemistry in abortive tissues and placentas. Enterovirus serotypes were confirmed by genome sequencing. Herpesviruses were detected by PCR.ResultsCoxsackievirus B3 (CVB3) was detected in 8 of 14 missed abortion cases, 1 of 27 full-term cases, and none of the 9 pre-term cases. Coxsackievirus B1 (CVB1) was detected in an encephalocele case. Herpes simplex virus type 1 was found in 4 full-term cases, 3 pre-term cases, and none of the missed abortion cases.ConclusionThe prevalence of CVB3 was significantly higher in missed abortion cases compared to full-term or pre-term delivery cases. CVB infection may therefore be an important etiological agent of missed abortion.

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