• VugtSaskia vanSvUniversity Medical Center Utrecht, Julius Center for Health, Sciences and Primary Care, Utrecht, the Netherlands., Lidewij Broekhuizen, Nicolaas Zuithoff, Christopher Butler, Kerenza Hood, Samuel Coenen, Herman Goossens, Paul Little, Jordi Almirall, Francesco Blasi, Slawomir Chlabicz, Mel Davies, Maciek Godycki-Cwirko, Helena Hupkova, Janko Kersnik, Michael Moore, Tom Schaberg, An De Sutter, Antoni Torres, Theo Verheij, and GRACE Project Group.
• University Medical Center Utrecht, Julius Center for Health, Sciences and Primary Care, Utrecht, the Netherlands.
• Ann Fam Med. 2012 Nov 1; 10 (6): 523-9.

PurposeWe sought to determine the prevalence of airway obstruction and bronchodilator responsiveness in adults consulting for acute cough in primary care.MethodsFamily physicians recruited 3,105 adult patients with acute cough (28 days or shorter) attending primary care practices in 12 European countries. After exclusion of patients with preexisting physician-diagnosed asthma or chronic obstructive pulmonary disease (COPD), we undertook complete case analysis of spirometry results (n = 1,947) 28 to 35 days after inclusion. Bronchodilator responsiveness was diagnosed if there were recurrent complaints of wheezing, cough, or dyspnea and an increase of the forced expiratory volume in 1 second (FEV(1)) of 12% or more after bronchodilation. Airway obstruction was diagnosed according to 2 thresholds for the (postbronchodilator) ratio of FEV(1) to forced vital capacity (FEV(1):FVC): less than 0.7 and less than the lower limit of normal.ResultsThere were 240 participants who showed bronchodilator responsiveness (12%), 193 (10%) had a FEV(1)/FVC ratio of less than 0.7, and 126 (6%) had a ratio of less than the lower limit of normal. Spearman's correlation between the 2 definitions of obstruction was 0.71 (P <.001), with discordance most pronounced among those younger than 30 years and in older participants.ConclusionsBoth bronchodilator responsiveness and persistent airway obstruction are common in adults without established asthma or COPD who consult for acute cough in primary care, which suggests a high risk of undiagnosed asthma and COPD. Different accepted methods to define airway obstruction detected different numbers of patients, especially at the extremes of age. As both conditions benefit from appropriate and timely interventions, clinicians should be aware and responsive to potential underdiagnosis.

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