• Fernanda Gomes, Guilherme Eustáquio Furtado, Mariana Henriques, Liliana Baptista Sousa, Paulo Santos-Costa, Rafael Bernardes, João Apóstolo, Pedro Parreira, and Anabela Salgueiro-Oliveira.
• LIBRO - Laboratório de Investigação em Biofilmes Rosário Oliveira, CEB, Centre of Biological Engineering, University of Minho, Braga, Portugal.
• Eur. J. Clin. Invest. 2022 Jan 1; 52 (1): e13688.

BackgroundPressure ulcers (PUs) are injuries resulting from ischaemia caused by prolonged compression or shear forces on the skin, adjacent tissues and bones. Advanced stages of PUs are associated with infectious complications and constitute a major clinical challenge, with high social and economic impacts in health care.GoalsThis study aims to identify and describe the relationship between PU risk factors, stages and anatomical locations, and the relevance of microbial cohabitation and biofilm growth.MethodsThe narrative review method to advocating a critical and objective analysis of the current knowledge on the topic was performed. Indexed databases and direct consultation to specialized and high-impact journals on the subject were used to extract relevant information, guided by co-authors. The Medical Subject Headings of pressure ulcer (or injury), biofilms, infection and other analogues terms were used.ResultsDevelopment of PUs and consequent infection depends on several direct and indirect risk factors, including cutaneous/PU microbiome, microclimate and behavioural factors. Infected PUs are polymicrobial and characterized by biofilm-associated infection, phenotypic hypervariability of species and inherent resistance to antimicrobials. The different stages and anatomical locations also play an important role in their colonization. The prevention and monitoring of PUs remain crucial for avoiding the emergence of systemic infections and reducing health care-associated costs, improve the quality of life of patients and reduce the mortality-associated infected PUs.© 2021 Stichting European Society for Clinical Investigation Journal Foundation. Published by John Wiley & Sons Ltd.

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