• J. Intern. Med. · Jul 2013

    Randomized Controlled Trial Multicenter Study

    Effects of an isocaloric healthy Nordic diet on insulin sensitivity, lipid profile and inflammation markers in metabolic syndrome -- a randomized study (SYSDIET).

    • M Uusitupa, K Hermansen, M J Savolainen, U Schwab, M Kolehmainen, L Brader, L S Mortensen, L Cloetens, A Johansson-Persson, G Onning, M Landin-Olsson, K-H Herzig, J Hukkanen, F Rosqvist, D Iggman, J Paananen, K J Pulkki, M Siloaho, L Dragsted, T Barri, K Overvad, K E Bach Knudsen, M S Hedemann, P Arner, I Dahlman, G I A Borge, P Baardseth, S M Ulven, I Gunnarsdottir, S Jónsdóttir, I Thorsdottir, M Orešič, K S Poutanen, U Risérus, and B Akesson.
    • Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland. matti.uusitupa@uef.fi
    • J. Intern. Med. 2013 Jul 1; 274 (1): 52-66.

    BackgroundDifferent healthy food patterns may modify cardiometabolic risk. We investigated the effects of an isocaloric healthy Nordic diet on insulin sensitivity, lipid profile, blood pressure and inflammatory markers in people with metabolic syndrome.MethodsWe conducted a randomized dietary study lasting for 18-24 weeks in individuals with features of metabolic syndrome (mean age 55 years, BMI 31.6 kg m(-2) , 67% women). Altogether 309 individuals were screened, 200 started the intervention after 4-week run-in period, and 96 (proportion of dropouts 7.9%) and 70 individuals (dropouts 27%) completed the study, in the Healthy diet and Control diet groups, respectively. Healthy diet included whole-grain products, berries, fruits and vegetables, rapeseed oil, three fish meals per week and low-fat dairy products. An average Nordic diet served as a Control diet. Compliance was monitored by repeated 4-day food diaries and fatty acid composition of serum phospholipids.ResultsBody weight remained stable, and no significant changes were observed in insulin sensitivity or blood pressure. Significant changes between the groups were found in non-HDL cholesterol (-0.18, mmol L(-1) 95% CI -0.35; -0.01, P = 0.04), LDL to HDL cholesterol (-0.15, -0.28; -0.00, P = 0.046) and apolipoprotein B to apolipoprotein A1 ratios (-0.04, -0.07; -0.00, P = 0.025) favouring the Healthy diet. IL-1 Ra increased during the Control diet (difference -84, -133; -37 ng L(-1) , P = 0.00053). Intakes of saturated fats (E%, beta estimate 4.28, 0.02; 8.53, P = 0.049) and magnesium (mg, -0.23, -0.41; -0.05, P = 0.012) were associated with IL-1 Ra.ConclusionsHealthy Nordic diet improved lipid profile and had a beneficial effect on low-grade inflammation.© 2013 The Association for the Publication of the Journal of Internal Medicine.

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