• Stojanka Gasparović, Nadan Rustemović, Milorad Opacić, Marina Premuzić, Andelko Korusić, Jadranka Bozikov, and Tamara Bates.
• Department of Anesthesiology, Dubrava University Hospital, Zagreb, Croatia.
• World J Gastroentero. 2006 Jan 14; 12 (2): 327-30.

AimTo analyze the hemodynamic and respiratory effects of propofol on patients undergoing gastroscopy and colonoscopy.MethodsIn this prospective study, conducted over a period of three years, 1,104 patients referred for a same day GI endoscopy procedure were analyzed. All patients were given a propofol bolus (0.5-1.5 mg/kg). Arterial blood pressure (BP) was monitored at 3 min intervals and heart rate and oxygen saturation (SpO2) were recorded continuously by pulse oximetry. Analyzed data acquisition was carried out before, during, and after the procedure.ResultsA statistically significant reduction in mean arterial pressure was demonstrated (P < 0.001) when compared to pre-intervention values, but severe hypotension, defined as a systolic blood pressure below 60 mmHg, was noted in only 5 patients (0.5%). Oxygen saturation decreased from 96.5% to 94.4 % (P < 0.001). A critical decrease in oxygen saturation (< 90%) was documented in 27 patients (2.4%).ConclusionOur results showed that propofol provided good sedation with excellent pain control, a short recovery time and no significant hemodynamic side effects if carefully titrated. All the patients (and especially ASA III group) require monitoring and care of an anesthesiologist.

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