• Thyyar M Ravindranath, Amanda Gomez, Ilana Harwayne-Gidansky, Thomas J Connors, Nathan Neill, Bruce Levin, Joy D Howell, Lisa Saiman, and John S Baird.
• Department of Pediatrics, NewYork-Presbyterian Hospital, Columbia University Medical Center, New York, New York.
• Pediatr. Pulmonol. 2018 Jul 1; 53 (7): 929-935.

ObjectivesTo study the incidence, risk factors, clinical course, and outcome of ARDS in children with HMP and RSV.Working HypothesisWe hypothesized that ARDS in children with HMP was similar in incidence, risk factors, clinical course, and outcomes to ARDS in children with RSV.Study DesignRetrospective, observational study over 2 years.Patient Subject SelectionPatients included were <18 years old with HMP or RSV detected from nasopharyngeal specimens by commercial reverse transcriptase polymerase chain reaction assay admitted to a study site.MethodologyWe described the incidence of ARDS within 1 week following the detection of HMP or RSV using recently developed Pediatric ARDS (PARDS) criteria. We also assessed risk factors, clinical course, and outcomes of children in the PICU with HMP or RSV and PARDS or non-PARDS.ResultsWe identified 57 patients with HMP and 161 patients with RSV: the proportions of patients with either virus who developed PARDS (HMP: 23%, RSV: 20%) and severe PARDS (HMP: 9%, RSV: 7%) were similar, as were the proportions of patients with acute (or acute-on-chronic) respiratory failure who developed PARDS (HMP: 41%, RSV: 31%). In a logistic regression model, risk factors associated with PARDS included neurologic comorbidity and PIM 3 probability of mortality, but not virus type. The risk factors, clinical course, and outcomes were similar for patients with PARDS associated with HMP and RSV.ConclusionsAbout 1/3 of children with HMP or RSV and acute (or acute-on-chronic) respiratory failure developed PARDS. Children with either virus and a neurologic comorbidity or an increased PIM 3 probability of mortality were at increased risk for PARDS.© 2018 Wiley Periodicals, Inc.

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