• Robert E Hunger, Sarina Angermeier, S Morteza Seyed Jafari, Adrian Ochsenbein, and Maziar Shafighi.
• University Clinic for Dermatology, Bern University Hospital, Inselspital, Bern, Switzerland.
• J. Am. Acad. Dermatol. 2015 Jun 1; 72 (6): 1054-9.

BackgroundMost guidelines recommend at least 2-cm excision margin for melanomas thicker than 2 mm.ObjectiveWe evaluated whether 1- or 2-cm excision margins for melanoma (>2 mm) result in different outcomes.MethodsThis is a retrospective cohort study on patients with melanomas (>2 mm) who underwent tumor excision with 1-cm (228 patients) or 2-cm (97 patients) margins to investigate presence of local recurrences, locoregional and distant metastases, and disease-free and overall survival.ResultsIn all, 325 patients with mean age of 61.84 years and Breslow thickness of 4.36 mm were considered for the study with a median follow-up of 1852 days (1995-2012). There was no significant difference in the frequency of locoregional and distant metastasis between the 2 groups (P = .311 and .571). The survival analysis showed no differences for disease-free (P = .800; hazard ratio 0.948; 95% confidence interval 0.627-1.433) and overall (P = .951; hazard ratio 1.018; 95% confidence interval 0.575-1.803) survival.LimitationsThe study was not prospectively randomized.ConclusionsOur study did not show any significant differences in important outcome parameters such as local or distant metastases and overall survival. A prospective study testing 1- versus 2-cm excision margin is warranted.Copyright © 2015 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.

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