• Neurology · Aug 2004

    Case Reports

    Cramps, muscle pain, and fasciculations: not always benign?

    • Mamede de Carvalho and Michael Swash.
    • EMG Laboratory, Institute of Molecular Medicine, University of Lisbon, Portugal. mamedemg@mail.telepac.pt
    • Neurology. 2004 Aug 24; 63 (4): 721-3.

    AbstractFasciculation and cramps without weakness or muscle atrophy are recognized as a benign syndrome. The authors report a patient with cramp and fasciculation, which persisted for 1 year without abnormal motor unit morphology on EMG before progressive weakness, muscle atrophy, and EMG abnormalities developed. This observation raises the possibility that lower motor neuron hyperexcitability may precede motor neuron death in motor neuron disease.

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