• I-Ching Lin, Yu-Wen Yang, Mei-Feng Wu, Yi-Hui Yeh, Jenn-Chang Liou, Ying-Li Lin, and Chih-Hsiang Chiang.
• Family Medicine Department, Changhua Christian Hospital, No, 135, St, Nan-Xiao, Changhua City 500, Taiwan. a102067@cmu.edu.tw.
• Bmc Fam Pract. 2014 Jul 29; 15: 138.

BackgroundTo investigate the association between metabolic syndrome, including its factors, and gallstone disease (GSD) in a Taiwanese population.MethodsWe conducted a cross-sectional study during 2011 ~ 2012. A total of 12050 subjects who completed a questionnaire and underwent physical examination, laboratory tests and abdominal ultrasonography formed the study population.ResultsThe prevalences of metabolic syndrome and gallstone disease were 24.09% and 6.16%. In an age- and sex-adjusted logistic regression model, metabolic syndrome was associated with gallstone disease (OR = 1.61; P < 0.0001). Age, abdominal obesity, and lower high-density lipoprotein cholesterol were associated with gallstone disease after adjusting for other factors. Females had a higher odds ratio than males in waist circumference for GSD, whereas males had a lower odds ratio than females in HDL-C for GSD.ConclusionsThe present study suggests that metabolic syndrome is related to gallstone disease. Waist circumference and high-density lipoprotein cholesterol are all associated with GSD. Men and women may possibly have different priorities and strategies to reduce the burden of GSD.

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