• J. Korean Med. Sci. · Oct 2013

    Case Reports

    Secondary prophylaxis of docetaxel induced diarrhea with loperamide: case report.

    • Hee Yeon Lee, Youn Hee Lee, Min Ji Kim, and Hoon-Kyo Kim.
    • Division of Medical Oncology, Department of Internal Medicine, St. Vincent's Hospital, The Catholic University of Korea, Suwon, Korea.
    • J. Korean Med. Sci. 2013 Oct 1; 28 (10): 1549-51.

    AbstractDiarrhea is a common adverse event of docetaxel with 20%-40% of incidence and severe diarrhea occurs in 5%-6%. Several treatment guidelines for chemotherapy induced diarrhea (CID) exist, however the prophylaxis for that is not well known. We describe a new prophylactic approach for the CID with loperamide. A 72-yr-old male patient with stage IV non-small-cell lung cancer developed diarrhea repeatedly after docetaxel-cisplatin chemotherapy. His diarrhea persisted despite treatment including loperamide and fasting. However, the diarrhea was successfully prevented when loperamide was given before and after the chemotherapy. To our knowledge, this is the first report of prophylactic approach for the CID with loperamide.

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