• J. Korean Med. Sci. · Oct 2013

    RET fusion genes in Korean non-small cell lung cancer.

    • Seung Soo Yoo, Guang Jin, Hye Jin Jung, Mi Jeong Hong, Jin Eun Choi, Hyo-Sung Jeon, Shin Yup Lee, Jeong Ok Lim, and Jae Yong Park.
    • Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea.
    • J. Korean Med. Sci. 2013 Oct 1; 28 (10): 155515581555-8.

    AbstractRecently, rearranged during transfection (RET) fusions have been identified in approximately 1% of non-small cell lung cancer (NSCLC). To know the prevalence of RET fusion genes in Korean NSCLCs, we examined the RET fusion genes in 156 surgically resected NSCLCs using a reverse transcriptase polymerase chain reaction. Two KIF5B-RET fusions and one CCDC6-RET fusion were identified. All three patients were females and never smokers with adenocarcinomas. RET fusion genes were mutually exclusive from EGFR, KRAS mutations and EML4-ALK fusion. RET fusion genes occur 1.9% (3 of 156) of surgically treated NSCLC patients in Koreans.

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