• J. Korean Med. Sci. · Nov 2013

    Comparison of specific IgE antibodies to wheat component allergens in two phenotypes of wheat allergy.

    • Young-Hee Nam, Eui-Kyung Hwang, Hyun Jung Jin, Jeong Min Lee, Yoo-Seob Shin, Young-Min Ye, Arantxa Palacin, Gabriel Salcedo, Soo-Young Lee, and Hae-Sim Park.
    • Department of Internal Medicine, Dong-A University School of Medicine, Busan, Korea.
    • J. Korean Med. Sci. 2013 Nov 1; 28 (11): 1697-9.

    AbstractSpecific IgE to gliadin was proposed as a marker for wheat dependent exercise induced anaphylaxis, while Tri a 14 was found to induce IgE response in baker's asthma. We evaluated whether these components could be used for discriminating phenotypes of wheat allergy. Twenty-nine patients who were wheat-induced anaphylaxis and/or urticaria (n=21, group I) and baker's asthma (n=8, group II) were enrolled. The prevalence of serum specific IgE to Tri a 14 was higher in group II (25%) than in group I (4.8%), while the serum specific IgE to gliadin was significantly higher in group I (70%) than in group II (12.5%). The cutoff value for predicting the baker's asthma using the ratio of serum specific IgE to Tri a 14 to gliadin was 742.8 optical density×1,000/(kU/L) with high sensitivity and specificity. These findings suggest that Tri a 14/gliadin may be a potential marker for predicting baker's asthma.

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